书名：Huntington’s disease
责任者：Gillian P. Bates | Sarah J. Tabrizi and Lesley Jones. | Jones, Lesley,
出版时间：2014
出版社：Oxford University Press,
摘要
This fourth edition presents a comprehensive summary of the current knowledge of the disease, including major scientific and clinical advances. The only technical monograph dedicated to Huntington's disease, it covers all aspects of the disease
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目录
Contributors vii
SECTION 1: CLINICAL ASPECTS OF HUNTINGTON'S DISEASE
1.Huntington's Disease in a Historical Context 3
2.Clinical Neurology 25
3.Neuropsychiatry and Neuropsychology 36
4.Juvenile Huntington's Disease 66
5.Premanifest and Early Huntington's Disease 86
SECTION 2: GENETICS OF HUNTINGTON'S DISEASE
6.Genetic and Molecular Studies 109
7.Epidemiology 131
8.Genetic Counseling and Testing 165
SECTION 3: NEUROBIOLOGY OF HUNTINGTON'S DISEASE
9.Neuropathology in the Human Brain 185
10.Altered Neuronal Circuitry 218
SECTION 4: MOLECULAR BIOLOGY OF HUNTINGTON'S DISEASE
11.Normal Function of Huntingtin 243
12.Structural Biology: Order, Disorder, and Conformational Flux 274
13.Pathogenic Mechanisms 323
14.Peripheral Pathology 370
SECTION 5: THERAPEUTIC INTERVENTIONS IN HUNTINGTON'S DISEASE
15.Comprehensive Care 393
16.Preclinical Experimental Therapeutics 410
17.Experimental Therapeutics: Moving Forward in Clinical Trials 462
Index 485
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馆藏单位
中国医科院医学信息研究所
