The vast number of uncharacterized genes and proteins found in different organisms has led to an unprecedented explosion of molecular biological information. This complex information will have tremendous implications on disease diagnosis, management, and treatment. This book provides insights into the understanding of function and structure of genes and proteins, and of biochemical, cellular, and molecular signaling networks. (Imprint: Nova)

Editorial ix

Biochemistry and Molecular Biology in Hong Kong: Past and Future xi

Research Articles 1

Chapter 1 Calpains-Mediated PTEN Cleavage in Excitotoxic Neuronal Death 3

Chapter 2 NUDCD2 Is Qverexpressed in Head and Neck Squamous Cell Carcinoma and Is Involved in Nuclear Division 19

Chapter 3 Genotype Analyses Using SNP (Using MALDI-TOFMass Spectrometry) and STR (Microsatellite) Markers in the Determination of Zygosity Status of Chinese Twins 41

Chapter 4 The Dyslexia Candidate Gene Kiaa0319L Encodes N-Glycosylated Isoforms That Form Homo-Dimers 55

Chapter 5 Identification of Feed Forward Loops Composed of MicroRNAs and Transcription Factors in Arabidopsis 69

Chapter 6 Proteomic Profiling of 6-Hydroxydopamine-Treated Zebrafish Using iTRAQ-2D LC-MS/MS Analysis 77

Chapter 7 Using Synthetic Lethality in the Targeted Treatment of Human Cancers 101

Brief Report 113

Chapter 8 Sanfilippo Syndrome: Identification and Removal of a Cryptic Splice Site in Alpha-N-Acetylglucosaminidase cDNA for Potential Improved Expression and Enzyme Replacement Therapy 115

Review 127

Chapter 9 Comparisons of EEG/QEEG Normative Databases and Review of Studies of Neurofeedback for Dyslexia 129

News 193

Chapter 10 Conference Report of 2010 Inter-University Post-Graduate Symposium 195

Chapter 11 Launching Theme-Based Research in Hong Kong 197

Chapter 12 Conference Report of 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium 199

Perspectives 203

Chapter 13 Chaos Theory in Astrophysics, Nature, Genetics, and Human Cancer 205

Paths to Success 213

Chapter 14 Forget About Competition and strike for the Best 215

Chapter 15 The Priceless Gift from Research and Experiments 217

Chapter 16 Crave for Improvements and Step Forward 219

Chapter 17 Try Hard, and Curiosity Will Lead to Success 221

Chapter 18 Back to the Road to Research 223

Appendix: Selected Abstracts from the 2010 Inter-University Post-Graduate Symposium Held in Hong Kong 225

Index 231

中国医科院医学信息研究所