This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.

Introduction to Stem Cells 1

Rob Burgess

Contemporary Ethical Issues in Stem Cell Research 29

Valerie Gutmann Koch, Beth E. Roxland, Barbara Pohl, and Sarah K. Keech

Part I Embryonic/Fetal Stem Cells

Stem Cells from Early Mammalian Embryos 41

Anna-Katerina Hadjantonakis, Svetlana Gavrilov, Panagiotis Xenopoulos, and Virginia E. Papaioannou

Quantitative Approaches to Model Pluripotency and Differentiation in Stem Cells 59

Dmitri Papatsenko, Huilei Xu, Avi Ma’ayan, and Ihor Lemischka

Growth Dynamics of Fetal Human Neural Stem Cells 75

Walter D. Niles, Dustin R. Wakeman, and Evan Y. Snyder Immunobiology of Embryonic and Induced Pluripotent Stem Cell Transplantation 91

Eleanor M. Bolton, J. Andrew Bradley, and Craig J. Taylor

Part II Pluripotent Stem Cells

Urodele Limb Regeneration: Mechanisms of Blastema Formation and Growth 107

David L. Stocum

Mechanism of miR-302-Mediated iPS Cell Generation 119

Shi-Lung Lin

Bioreactor Expansion of Pluripotent Stem Cells 129

Jaymi T. Taiani, Mehdi Shafa, and Derrick E. Rancourt

Generation of Hepatocyte-Like Cells from Human Pluripotent Stem Cells 139

Fallon K. Noto and Stephen A. Duncan

Neural Differentiation from Pluripotent Stem Cells 149

Mahendra Rao and Nasir Malik

Generation of Anterior Foregut Derivatives from Pluripotent Stem Cells 161

Hans-Willem Snoeck

Commercial Opportunities for Induced Pluripotent Stem Cells 177

Amy Lynnette Van Deusen and Rania Nasis

Part III Tissue Stem Cells

Spermatogonial Stem Cells in Adult Mice and Men 203

Courtney Sachs and Marco Seandel

Characterization of the Hematopoietic Stem Cell Niche: Cellular and Molecular Analysis 211

Charles Durand, Thomas Häupl, and Pierre Charbord

Glandular Stem Cells (GSCs): Stem Cells in Glandular Organs 223

Ming Jiang, Karin Williams, and Simon W. Hayward

Human Mammary Epithelial Stem/Progenitor Cells 235

Patricia J. Keller, Lisa M. Arendt, and Charlotte Kuperwasser

Mammary Epithelial Stem Cells 245

Brian W. Booth, Daniel Medina, and Gilbert H. Smith

Gastric Stem Cell Biology: Proliferation Kinetics, Differentiation Hierarchies, and Role in Carcinogenesis 255

Sherif M. Karam

Progenitors of Islet Cells 271

Isabelle Houbracken, Josue Kunjom Mfopou, and Luc Bouwens

Stem Cell Populations Giving Rise to Liver, Biliary Tree, and Pancreas 283

Mark E. Furth, Yunfang Wang, Vincenzo Cardinale, Guido Carpino,

Giacomo Lanzoni, Cai-Bin Cui, Eliane Wauthier, David Gerber, Tsunekazu Oikawa, Juan Dominguez-Bendala, Luca Inverardi, Domenico Alvaro, Eugenio Gaudio, and Lola M. Reid

Liver Regeneration in Health and Disease 311

Malcolm R. Alison and Shahriar Islam

Human-Induced Pluripotent Stem Cells, Embryonic Stem Cells, and Their Cardiomyocyte Derivatives: An Overview 321

Shiva Prasad Potta, Tomo Šarić, Michael Heke, and Jürgen Hescheler Potential of Glial Cells 347

Magdalena Götz and Swetlana Sirko

Stem Cells and Aging 363

Heidi Scrable and Susan Ashrafzadeh-Kian

Part IV Stem Cell Transplantation

Translating Stem Cell Discoveries 377

Alan Trounson

Mesenchymal Stromal/Stem Cell Transplantation: From Tissue Regeneration to Immune Modulation 391

Peiman Hematti

Stem Cells and Tissue Engineering in Burns and Wounds 399

Patrick H. Blit, Anna I. Arno, and Marc G. Jeschke

Derivation of Retinal Pigmented Epithelial Cells for the Treatment of Ocular Disease 411

Dennis O. Clegg, Sherry T. Hikita, Qirui Hu, Dave Buchholz, Teisha J. Rowland, Britney Pennington, Roxanne Croze, Lyndsay Leach, Marlene Tsie, Lisa Conti, and Lincoln V. Johnson

Stem Cells and Diabetes 419

Der-I Kao and Shuibing Chen

Part V Stem Cells and Cancer

Cancer Is a Problem of Developmental Biology: Maturation Arrest and the Hierarchical Model of the Origin of Cancer from Stem Cells 429

Stewart Sell and Pier Mario Biava

Targeting the Stem Cell Plasticity of Tumor Cells 441

Luigi Strizzi, Katharine M. Hardy, Thomas M. Bodenstine, and Mary J.C. Hendrix

Molecular Evolution of Leukemia Stem Cells 449

Leslie A. Crews and Catriona H.M. Jamieson

Rodent Models for Assessing the Role of Stem Cells in Liver Development, Regeneration, and Carcinogenesis 459

Jennifer A. Sanders and Douglas C. Hixson

Breast Cancer Stem Cells: From Theory to Therapy 477

Sarah J. Conley and Max S. Wicha

Nephroblastoma/Wilms Tumor: A Corrupted Cap Stem Cell Caricature 491

Michael D. Hall and Alan O. Perantoni

About the Editor 511

Index 513

Stewart Sell is a board certified pathologist and immunologist. He began research in 1957 while a medical student at the University of Pittsburgh, in the Department of Pathology, under Frank J. Dixon. After a pathology residency at Massachusetts Hospital, and post doctoral fellowships at NIH and Birmingham England he returned to the University of Pittsburgh for 5 years before moving to the University of California at San Diego. After 12 years at UCSD, Dr. Sell took the position as Chair of Pathology and Laboratory Medicine at the University of Texas (UT) at Houston before moving to Albany Medical College. As of February 2003 he has been a senior scientist at Wadsworth Center, a Professor at University at Albany School of Public Health and an Adjunct Professor at Albany College of Pharmacy. Dr. Sell received the Rudolph L. K. Virchow Award of the Italian Medical Magazine LeadershipMedica.com for his concept of cancer stem cells; he was named Legacy Laureate of the University of Pittsburgh for his work on alpha-fetoprotein as a marker for liver cancer; and in 2007 received the Abbott Award of the International Society for Oncodevelopmental Biology and Medicine for recognizing the role of stem cells in carcinogenesis. He has published over 400 papers and 12 books, including 6 editions of Immunology, Immunopathology and Immunity. His paper with Barry Pierce (Lab. Invest. 70:6-21, 1994.) was selected as an AACR scientific landmark.

中科院文献情报中心