This book is designed to provide a comprehensive review of both general and organ-specific pathology through multiple choice questions with explanations of the answers. The source materials are the ninth editions of Robbins and Cotran Pathologic Basis of Disease (PBD9) and Robbins Basic Pathology (BP9), and in several chapters, Robbins and Cotran Atlas of Pathology (AP3). The questions in this review book follow the chapters and topics in these source materials to facilitate ongoing self-assessment as students work their way through a curriculum to gain and then apply their understanding of key concepts. This book is intended to be a useful resource for students in a variety of health science training programs.
In keeping with recommended question writing style for licensing examinations, we have included single best-answer questions, most with a clinical vignette, followed by a series of homogenous choices. This approach emphasizes an understanding of pathophysiologic mechanisms and manifestations of disease in a clinical context. We have incorporated relevant laboratory, radiologic, and physical diagnostic findings in the questions to emphasize clinicopathologic correlations. Although this adds to the extent of individual questions, the thoroughness reinforces learning, as a review should. Each answer includes a succinct explanation of why a particular choice is "correct" and the other choices are "incorrect." Each answer is referenced by page numbers to both Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology (both the current ninth edition and the previous eighth edition of each), and in several cases, to figures in the third edition of Robbins and Cotran Atlas of Pathology, to facilitate and encourage a more complete reading of topics targeted for further review. Pathology is a visually oriented discipline; hence full-color images accompany many of the questions. The illustrations are taken mainly from the Robbins textbooks, so students can reinforce their study of the figures in the texts with questions that utilize the same or similar images.
The revisions in this fourth edition reflect new topics and new understanding of disease processes reflected in the most recent editions of the Robbins textbooks. The questions are intentionally written to be fairly difficult, with the purpose of "pushing the envelope" of students' understanding of pathology. We are pushing it even further with a comprehensive final examination section that includes questions drawn from challenging topics covered in the entire book.
Mastery of this book will better prepare the student for further challenges. Many of the questions require the student to engage in a "multi-step" process: first, to interpret the information presented to arrive at a diagnosis, and then to solve a problem based on that diagnosis. This reinforces the clinical reasoning skills needed in delivery of health care. We must hasten to add that no review book is a substitute for textbooks and other course materials provided by individual instructors within the context of a curriculum. This book should be used in conjunction with thorough study of Robbins and Cotran Pathologic Basis of Disease and/or Robbins Basic Pathology and curricular materials. Finally, we hope that bo th students and their faculty will find this review book to be a useful adjunct to the learning of pathology. Edward C. Klatt, MD Vinay Kumar, MBBS, MD, FRCPath

UNIT I: General Pathology

1 The Cell as a Unit of Health and Disease 3

2 Cellular Pathology 7

3 Inflammation and Repair 18

4 Hemodynamic Disorders 31

5 Genetic Disorders 44

6 Immune System Diseases 57

7 Neoplastic Disorders 76

8 Infectious Diseases 94

9 Environmental and Nutritional Diseases 114

10 Diseases of Infancy and Childhood 130

UNIT II:Diseases of Organ Systems

11 Blood Vessels 147

12 The Heart 163

13 Hematopathology of White Blood Cells 183

14 Hematopathology of Red Blood Cells and Bleeding Disorders 205

15 The Lung 226

16 Head and Neck 253

17 Gastrointestinal Tract 263

18 Liver and Biliary Tract 286

19 Pancreas 306

20 Kidney 312

21 The Lower Urinary Tract and Male Genital System 332

22 Female Genital Tract 344

23 The Breast 361

24 The Endocrine System 371

25 The Skin 392

26 Bones, Joints, and Soft Tissue Tumors 405

27 Peripheral Nerve and Skeletal Muscle 424

28 Central Nervous System 432

29 The Eye 456

30 Final Review and Assessment 464

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