One of the most important challenges in medicine is the accurate and timely detection of infectious diseases. Although this is primarily thought of as the domain of the microbiology laboratory, the anatomic pathologist plays an essential role in the identification of infectious organisms in surgical and cytological preparations. Indeed, there are many instances in which these preparations present the only opportunity for identifying the infecting organism, particularly when tissue was not submitted for culture or the organism fails to grow. The pathologist also has the opportunity to observe the host response associated with an infectious organism and thus make a judgment as to whether the presence of the organism represents colonization, contamination, or true infection.
Given the variety of organisms that may he seen in tissue, the anatomic pathologist must be familiar with the histologic and cytologic presentation of a variety of bacteria, viruses, fungi, and parasites. The goal of this text is therefore to provide a practical and easy-to-use reference for the practicing pathologist, with adequate information for correlating gross and microscopic pathologic features with clinical presentation and radiology findings.
We acknowledge that it takes many dedicated people to create a textbook that will add to the body of knowledge about infectious diseases. This textbook is a compilation of the creative works of outstanding contributors to whom we are truly grateful for sharing their expertise. In addition, we appreciate the support and encouragement from Elsevier editors. Gary W.Procop, MD, MS; Bobbi S. Pritt, MD, MSc, (D)TMH

SECTION 1 Approach to Infectious Disease Pathology

CHAPTER 1 Principles of Infectious Disease Pathology: An Introduction 3

SECTION 2 Viral Infections

CHAPTER 2 Herpes Virus Infections 17

CHAPTER 3 Viral Hepatitis 37

CHAPTER 4 Human Papillomavirus, Polyomaviruses, and Parvovirus Infections 49

CHAPTER 5 Human Immunodeficiency Virus Infection 70

CHAPTER 6 Influenza and Other Respiratory Virus Infections 105

CHAPTER 7 Arbovirus Encephalomyelitis 136

CHAPTER 8 Viral Encephalomyelitis: Rabies, Enterovirus, and LCM 176

CHAPTER 9 Orf Infections and Molluscum Contagiosum 193

SECTION 3 Bacterial Infections

CHAPTER 10 Skin and Soft Tissue Infections 209

CHAPTER 11 Endocarditis and Other Intravascular Infections 229

CHAPTER 12 Bacterial Pneumonia 247

CHAPTER 13 Nocardiosis and Infections by Related Species 265

CHAPTER 14 Mycetoma: Eumycetoma and Actinomycetoma 278

CHAPTER 15 Botryomycoses 292

CHAPTER 16 Bacterial Gastrointestinal Infections 297

CHAPTER 17 Anaerobic Bacterial Infections 326

CHAPTER 18 Bartonella, Coxiella, and Tropheryma Infections 346

CHAPTER 19 Rickettsia, Ehrlichia, and Anaplasma Infections 380

SECTION 4 Mycobacterial Infections

CHAPTER 20 Tuberculosis and Infections by Nontuberculous Mycobacteria 415

CHAPTER 21 Leprosy 434

CHAPTER 22 Buruli Ulcer 447

SECTION 5 Fungal Infections

CHAPTER 23 Hyalohyphomycoses 461

CHAPTER 24 Zygomycosis 491

CHAPTER 25 Dematiaceous Fungal Infections 516

CHAPTER 26 Infections with Yeast and Yeastlike Fungi 531

SECTION 6 Parasitic Infections

CHAPTER 27 Helminth Infections 575

CHAPTER 28 Protozoal Infections 610

SECTION 7 Artifacts and Pitfalls

CHAPTER 29 Artifacts and Pitfalls in Infectious Disease Pathology 647

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