前言
With all the regulatory changes, many physicians might agree with Virchow's lament. In Rheumatology, this has clearly not been the case. It has been a decade since the last edition of Rheumatology Secrets, and I am amazed with the advances that have occurred in both the science and treatment of the Rheumatic diseases. Each chapter in the present edition has been extensively reviewed and updated to include those advancements through January 2014.
I have frequently been asked why the long delay between editions? For many years I had the privilege of serving on the American Board of Internal Medicine Certifying Examination Committee in Rheumatology. As many use the Secrets to study for board certification and recertification I wanted to avoid what I considered a possible conflict of interest, With my term on the committee ended it is a pleasure to be able to edit this book again.
As in the previous editions, Rheumatology Secrets, Third Edition, is presented in the Socratic question and answer format that is the hallmark of The Secrets Series. The chapters are organized into 15 sections, each with a common theme emphasized by an introductory quotation. Common and uncommon rheumatic disease problems that we encounter in clinical practice, discuss during teaching rounds, and find on board examinations are covered. Each chapter reviews basic immunology and pathophysiology, important disease manifestations, and practical management issues. The book also contains a wealth of mnemonics, lists, tables, figures, and illustrations to emphasize important points. Chapter 2 lists some of the top Rheumatology Secrets and I encourage readers to send me their top secrets. I hope that the reader will find Rheumatology Secrets, Third Edition, both enjoyable and useful in daily practice. Sterling G. West, MD
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目录
I General Concepts
CHAPTER 1 CLASSIFICATION AND HEALTH IMPACT OF THE RHEUMATIC DISEASES 3
CHAPTER 2 TOP 100+RHEUMATOLOGY SECRETS 7
CHAPTER 3 ANATOMY AND PHYSIOLOGY OF THE MUSCULOSKELETAL SYSTEM 16
CHAPTER 4 OVERVIEW OF THE IMMUNE RESPONSE, INFLAMMATION, AND AUTOIMMUNITY 24
II Evaluation of the Patient wIth Rheumatic Symptoms
CHAPTER 5 HISTORY AND PHYSICAL EXAMINATION 41
CHAPTER 6 LABORATORY EVALUATION 48
CHAPTER 7 ARTHROCENTESIS AND SYNOVIAL FLUID ANALYSIS 58
CHAPTER 8 RADIOGRAPHIC AND IMAGING MODALITIES 63
CHAPTER 9 SYNOVIAL BIOPSIES 76
CHAPTER 10 ELECTROMYOGRAPHY AND NERVE CONDUCTION STUDIES 78
CHAPTER 11 APPROACH FOR PATIENTS WITH MONOARTICULAR ARTHRITIS SYMPTOMS 82
CHAPTER 12 APPROACH FOR PATIENTS WITH POLYARTICULAR ARTHRITIS SYMPTOMS 86
CHAPTER 13 APPROACH FOR THE PATIENT WITH NEUROMUSCULAR SYMPTOMS 91
CHAPTER 14 PERIOPERATIVE MANAGEMENT OF PATIENTS WITH RHEUMATIC DISEASES 96
III Systemic Connective Tissue Diseases
CHAPTER 15 RHEUMATOID ARTHRITIS 107
CHAPTER 16 SYSTEMIC LUPUS ERYTHEMATOSUS 119
CHAPTER 17 DRUG-INDUCED LUPUS 137
CHAPTER 18 SYSTEMIC SCLEROSIS 141
CHAPTER 19 SCLERODERMA MIMICS 154
CHAPTER 20 INFLAMMATORY MUSCLE DISEASE 158
CHAPTER 21 MIXED CONNECTIVE TISSUE DISEASE,OVERLAP SYNDROMES, AND UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE 166
CHAPTER 22 SJOGREN'S SYNDROME 171
CHAPTER 23 ANTIPHOSPHOLIPID ANTIBODY SYNDROME 179
CHAPTER 24 ADULT-ONSET STILL'S DISEASE 189
CHAPTER 25 POLYMYALGIA RHEUMATICA 193
IV the vasculitides and related Disorders
CHAPTER 26 APPROACH FOR PATIENTS WITH SUSPECTED VASCULITIS 201
CHAPTER 27 LARGE-VESSEL VASCULITIS: GIANT CELL ARTERITIS, TAKAYASU ARTERITIS, AND AORTITIS 208
CHAPTER 28 MEDIUM-VESSEL VASCULITIDES: POLYARTERITIS NODOSA, THROMBOANGIITIS OBLITERANS, AND PRIMARY ANGIITIS OF THE CENTRAL NERVOUS SYSTEM 216 CHAPTER 29 ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS 224
CHAPTER 30 IMMUNE-COMPLEX-MEDIATED SMALL-VESSEL VASCULITIDES 236
CHAPTER 31 CRYOGLOBUUNEMIA 241
CHAPTER 32 BEHgET'S DISEASE AND COGAN'S SYNDROME 248
CHAPTER 33 RELAPSING POLYCHONDRITIS 253
V SEronegative SPondyloarthropathies
CHAPTER 34 ANKYLOSING SPONDYLITIS 261
CHAPTER 35 RHEUMATIC MANIFESTATIONS OF GASTROINTESTINAL AND HEPATOBIUARY DISEASES 268
CHAPTER 36 REACTIVE ARTHRITIS 276
CHAPTER 37 ARTHRITIS ASSOCIATED WITH PSORIASIS AND OTHER SKIN DISEASES 284
VI Arthritis Associated with Infectious Agents
CHAPTER 38 BACTERIAL SEPTIC ARTHRITIS, BURSITIS, AND OSTEOMYELITIS 291
CHAPTER 39 LYME DISEASE 300
CHAPTER 40 MYCOBACTERIAL AND FUNGAL JOINT AND BONE DISEASES 307
CHAPTER 41 VIRAL ARTHRITIDES 313
CHAPTER 42 HIV-ASSOCIATED RHEUMATIC SYNDROMES 319
CHAPTER 43 WHIPPLE'S DISEASE 325
CHAPTER 44 ACUTE RHEUMATIC FEVER AND POSTSTREPTOCOCCAL ARTHRITIS 328
VII Rheumatic Disorders Associated with Metabolic, Endocrine, and Hematologic Diseases
CHAPTER 45 GOUT 337
CHAPTER 46 CALCIUM PYROPHOSPHATE DEPOSITION DISEASE 346
CHAPTER 47 BASIC CALCIUM PHOSPHATE AND OTHER CRYSTALLINE DISEASES 352
CHAPTER 48 ENDOCRINE-ASSOCIATED ARTHROPATHIES 357
CHAPTER 49 ARTHROPATHIES ASSOCIATED WITH HEMATOLOGIC DISEASES 365
CHAPTER 50 MALIGNANCY-ASSOCIATED RHEUMATIC DISORDERS 371
VIII Bone and Cartilage Disorders
CHAPTER 51 OSTEOARTHRITIS 381
CHAPTER 52 METABOLIC BONE DISEASE 393
CHAPTER 53 PAGET'S DISEASE OF BONE 400
CHAPTER 54 OSTEONECROSIS 405
IX Hereditary, Congenital, and Inborn Errors of Metabolism Associated with Rheumatic Syndromes
CHAPTER 55 heritable connective tissue diseases 413
CHAPTER 56 INBORN ERRORS OF METABOLISM AFFECTING CONNECTIVE TISSUE 420
CHAPTER 57 STORAGE AND DEPOSITION DISEASES 424
CHAPTER 58 RHEUMATOLOGIC MANIFESTATIONS OF THE PRIMARY IMMUNODEFICIENCY SYNDROMES 430
CHAPTER 59 BONE AND JOINT DYSPLASIAS 437
X NONARTICULAR AND REGIONAL MUSCULOSKELETAL DISORDERS
CHAPTER 60 APPROACH FOR THE PATIENT WITH NECK AND LOW BACK PAIN 445
CHAPTER 61 FIBROMYALGIA 452
CHAPTER 62 REGIONAL MUSCULOSKELETAL DISORDERS 462
CHAPTER 63 SPORTS MEDICINE AND OCCUPATIONAL INJURIES 471
CHAPTER 64 ENTRAPMENT NEUROPATHIES 477
CHAPTER 65 COMPLEX REGIONAL PAIN SYNDROME 483
XI Neoplasms and TumorLike Lesions
CHAPTER 66 BENIGN AND MALIGNANT TUMORS OF JOINTS AND SYNOVIUM 493
CHAPTER 67 COMMON BONY LESIONS: RADIOGRAPHIC FEATURES 497
XII Pediatric Rheumatic Diseases
CHAPTER 68 APPROACH TO THE CHILD WITH JOINT PAIN 509
CHAPTER 69 JUVENILE IDIOPATHIC ARTHRITIS 516
CHAPTER 70 JUVENILE SYSTEMIC CONNECTIVE TISSUE DISEASES 522
CHAPTER 71 KAWASAKI DISEASE 530
XIII Miscellaneous Rheumatic Disorders
CHAPTER 72 METABOLIC AND OTHER GENETIC MYOPATHIES 535
CHAPTER 73 AMYLOIDOSIS 543
CHAPTER 74 RAYNAUD'S PHENOMENON 549
CHAPTER 75 AUTOIMMUNE EYE AND EAR DISORDERS 555
CHAPTER 76 RHEUMATIC SYNDROMES ASSOCIATED WITH SARCOIDOSIS 565
CHAPTER 77 RHEUMATIC DISORDERS IN PATIENTS ON DIALYSIS 571
CHAPTER 78 RHEUMATIC DISEASE AND THE PREGNANT PATIENT 577
CHAPTER 79 FAMILIAL AUTOINFLAMMATORY SYNDROMES 586
CHAPTER 80 ODDS AND ENDS 592
XIV Management of the rheumatic Diseases
CHAPTER 81 NONSTEROIDAL ANTIINFLAMMATORY DRUGS 601
CHAPTER 82 GLUCOCORTICOIDS—SYSTEMIC AND INJECTABLE 612
CHAPTER 83 SYSTEMIC ANTIRHEUMATIC DRUGS 619
CHAPTER 84 IMMUNOSUPPRESSIVE AND IMMUNOREGULATORY AGENTS 627
CHAPTER 85 BIOLOGIC AGENTS 633
CHAPTER 86 HYPOURICEMIC AGENTS AND COLCHICINE 645
CHAPTER 87 BONE STRENGTHENING AGENTS 652
CHAPTER 88 REHABILITATIVE TECHNIQUES 661
CHAPTER 89 SURGICAL TREATMENT AND RHEUMATIC DISEASES 668
CHAPTER 90 DISABILITY 676
XV Final Secrets
CHAPTER 91 COMPLEMENTARY AND ALTERNATIVE MEDICINE 685
CHAPTER 92 HISTORY, THE ARTS, AND RHEUMATIC DISEASES 692
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中国医科院医学信息研究所
