This volume of International Review of Neurobiology is on Cerebellar Conditioning and Learning. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field.

Contributors vii

1.Learning-Induced Structural Plasticity in the Cerebellum 1

1.Introduction 2

2.Learning-Induced Structural Plasticity at Parallel Fiber-Purkinje Cell Synapses 3

3.Structural Plasticity Other than Parallel Fiber-Purkinje Cell Synapses 10

4.Conclusion 13

Acknowledgments 14

References 14

2.Cerebellar Mechanisms of Learning and Plasticity Revealed by Delay Eyelid Conditioning 21

1.Introduction 21

2.Eyelid Conditioning as a Tool to Study the Cerebellum 23

3.Sites and Rules for Learning-Related Plasticity 25

4.The Role of Timing in Cerebellar Learning 26

5.Feedback Control of Climbing Fiber Equilibrium Activity 29

6.The Role of Feedback Inhibition of Climbing Fibers in Response Timing 31

7.Implications for Cerebellar Learning from the Phenomenon of Savings 32

8.Summary 34

References 35

3.Cerebellar Long-Term Potentiation: Cellular Mechanisms and Role in Learning 39

1.The Search for the Memory Engram in Cerebellar Learning 39

2.LTP: Cellular Mechanisms 40

3.Conflicting Data on the Role of Calcineurin in LTD Induction 45

4.LTP and Cerebellar Learning 46

Acknowledgments 48

References 48

4.The Ontogeny of Associative Cerebellar Learning 53

1.Introduction 54

2.Behavioral Ontogeny of Eyeblink Conditioning 54

3.Neural Mechanisms Underlying Eyeblink Conditioning 56

4.Neural Mechanisms Underlying the Ontogeny of Eyeblink Conditioning 60

5.Conclusions 65

References 67

Index 73

Contents of Previous Volumes 75

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