The history of the study of proteolytic enzymes (peptidases) can be traced back at least to the late eighteenth century, but in recent times the work has accelerated greatly, fuelled by numerous practical applications in biotechnology, and the realization that these enzymes are major therapeutic targets. Notably, the success of inhibitors of angiotensin converting enzymes for the treatment of hypertension, and retropepsin in the treatment of AIDS has provided an unambiguous validation of the principle that peptidase inhibitors can be successful drugs.
The many ways in which proteolytic enzymes impinge on the health and welfare of mankind have made it essential for biological scientists to have ready access to data on peptidases, but the sheer numbers of these enzymes pose a problem. Analysis of complete data on over a hundred genomes has shown that about two percent of all gene products are peptidases, indicating that this is one of the larger functional groups of proteins. The great number of known peptidases creates many practical problems for those needing to work with them. For example, it can be difficult to know how one peptidase can be distinguished from another, how knowledge of one peptidase can help with understanding related peptidases, and how a scientist can recognize a truly novel peptidase. It is such problems that a comprehensive resource such as the present Handbook is designed to help with.
The present volume has grown out of a longstanding interest of the editors in preparing readily accessible compilations of data on peptidases. Its genesis can be traced back to the 2nd International Symposium on Intracellular Protein Catabolism organized in Ljubljana, Slovenia, in 1975, by Vito Turk. Two of the original editors (AJB and JFW) recognized that there was the potential for confusion over the various intracellular proteolytic enzymes and how they might be distinguished. A brief document was prepared with the collaboration of I. Kregar and V. Turk, entitled “Present knowledge of proteolytic enzymes and their inhibitors”，and this was published in the proceedings of the conference, Intracellular Protein Catabolism II (V. Turk & N. Marks eds, Plenum Press, New York, 1977). A grand total of 23 intracellular enzymes were tabulated! This modest beginning was followed by Mammalian Proteases: a Glossary and Bibliography by AJB with J. Ken McDonald in two volumes (Academic Press，London, 1980，1986). Here, 173 peptidases were described in concise summaries supplemented by bibliographies. However, these books have long been out of print.
During the 1990s, two of the original editors (AJB, NDR) worked to make use of the wealth of data for the sequences and structures of peptidases that were beginning to appear. They used it as the basis of a new system for the classification of peptidases in which the enzymes were allocated to clans and families within each major mechanistic class. This new classification provided the structure for the MEROPS database when first published on the World Wide Web in 1996. The database formed an easily updatable reference resource containing summary data on all the peptidases. However, it was felt that what was also needed was a supplementary data source which, although not as up-to-date as the website, would provide much a fuller account of the individual peptidases, each having been written by an expert on the enzyme. This resulted in the publication in 1998 of the first edition of the Handbook of Proteolytic Enzymes.
The rapid progress of research on proteolytic enzymes continued unabated, and soon after the first publication of the Handbook it was clear that a second edition was needed. Another eight years later, and it was clear that a third edition was required. This present edition contains a great deal of new material; almost all of the chapters have been updated, and there are many new ones. The number of peptidases included now totals well over 1000，and a similar number of authors have worked hard and well to describe these peptidases in the format required for the Handbook. We thank them all for their good work.
The present editors wish to take this opportunity to thank the editors of the previous two editions, Alan Barrett (AJB) and Fred Woessner (JFW), who did so much of the original work to establish the style for each chapter. We would also like to thank the team at Elsevier Science, especially Will Smaldon, Janice Audet, and Jacqui Holding for their essential contributions. Finally, we express our heartfelt, personal appreciation to our wives, Cheow-Yong Rawlings and Anna Salvesen, who patiently tolerated our preoccupation with the Handbook during the past several years.

Editor Biographies xxxiii

Contributors xxxv

Preface xlix

Introduction li

SERINE AND THREONINE PEPTIDASES

559. Introduction: Serine Peptidases and Their Clans [Neil D. Rawlings and Alan J. Barrett] 2491

560. Catalytic Mechanisms of Serine and Threonine Peptidases [Laszlo Polgar] 2524

561. Glutamyl Endopeptidase I [Henning R. Stennicke and Klaus Breddam] 2534

562. Exfoliative Toxins — Staphylococcal Epidermolysins [Gilles Prevost] 2539

563. Lysyl Endopeptidase [Fumio Sakiyama and Takeharu Masaki] 2543

564. Streptogrisin A [Mohammad A Qasim] 2546

565. Streptogrisin B [Mohammad A. Qasim] 2549

566. Glutamyl Endopeptidase II [Henning R. Stennicke and Klaus Breddam] 2556

567. α-Lytic Protease [Sheila S. Jaswal, Cynthia N. Fuhrmann, Nobuyuki Ota, Stephen D. Rader and David A. Agard] 2558

568. Yeast-Lytic Endopeptidase (Rarobacter)[Hitoshi Shimoi] 2565

569. DegP Protease [Niklas Weber and Harald Kolmar] 2567

570. HtrA2 Peptidase [L. Miguel Martins] 2571

571. HtrA1 Peptidase [Jeremy Chien and Viji Shridhar] 2577

572. HtrA3 Peptidase [Daniah BeIeford and Viji Shridhar] 2584

573. Trypsin (Streptomyces exfoliates and S. albidoflavus)[Kye Joon Lee, Sung Gyun Kang and In Seop Kim] 2590

574. Trypsin (Saccharopolyspora erythraeus)[Shigemi Norioka and Fumio Sakiyama] 2592

575. Trypsin [Teaster T. Baird, Jr. and Charles S. Craik] 2594

576. Human Trypsins [Jian-Min Chen, Evette S. Radisky and Claude Ferec] 2600

577. Cationic Trypsin (Human)[Jian-Min Chen and Claude Ferec] 2609

578. Anionic Trypsin (Human)[Jian-Min Chen and Claude Ferec] 2614

579. Neurotrypsin [Peter Sonderegger] 2616

580. Trypsin I in Fish [Agusta Gudmundsdottir, Bjarki Stefansson and Jon Bragi Bjamason] 2621

581. Metridin [Alan J. Barrett] 2624

582. Chymotrypsin [Laszlo Graf, Laszlo Szilagyi and Istvan Venekei] 2626

583. Chymotrypsin C [Laszlo Szilagyi] 2634

584. Pancreatic Elastases [Eduardo Brandt de Oliveira and Maria Cristina O. Salgado] 2639

585. Cercarial Elastase (Schistosoma)[James H. McKerrow, Jessica Ingram and Landys Lopez-Quezada] 2646

586. Enteropeptidase [J. Evan Sadler] 2648

587. Elastase-2/Leukocyte Elastase [Brice Korkmaz and Francis Gauthier] 2653

588. Cathepsin G [Guy S. Salvesen] 2661

589. Myeloblastin [Narayanam V. Rao and John R. Hoidal] 2666

590. Chymases [George H. Caughey] 2675

591. Human α-, β- and 8-Tryptases [Neil N, Trivedi and George H. Caughey] 2683

592. r-Tryptase [Neil N. Trivedi and George H. Caughey] 2694

593. Mouse Mast Cell Tetramer-forming Tryptases [Dominick Zheng and Richard L. Stevens] 2698

594. Mastins [George H. Caughey] 2706

595. Marapsin [Kavita Raman and George H. Caughey] 2709

596. Bovine Duodenase and Sheep Mast Cell Proteinase-1 [Alan D. Pemberton] 2712

597. Granzyme A [Christopher J. Froelich] 2715

598. Granzyme B [Christopher J. Froelich] 2718

599. Granzyme H [Felipe Andrade and Dieter E, Jenne] 2721

600. Granzyme K [Niels Bovenschen] 2725

601. Granzyme M [Mark J. Smyth, Daniel M. Andrews and Nikola Baschuk] 2728

602. Acrosin [Ibrahim M. Adham, Manfred Schlosser and Wolfgang Engel] 2731

603. Xenopus Oviductin [L. L Lindsay] 2736

604. Spermosin [Hitoshi Sawada] 2738

605. Strypsin 1 [Navneet Sharma and Derrick E. Rancourt] 2740

606. The Human Tissue Kallikrein and Kallikrein-related Peptidase Family [Judith A. Clements, John D. Hooper and Ying Dong] 2747

607. Human Kallikrein 1,Tissue Kallikrein [Julie Chao] 2757

608. Human Kallikrein-related Peptidase 2 [Julie Chao, Li-Mei Chen and Karl X. Chai] 2762

609. Human Kallikrein-related Peptidase 3, the Prostate-specific Antigen [Julie Chao, Karl X. Chai and Li-Mei Chen] 2765

610. Kallikrein-Related Peptidase 4 [James P. Simmer] 2768

611. Kallikrein-Related Peptidase 5 [Peter Goettig and Viktor Magdolen] 2772

612. Kallikrein-related Peptidase 6 [Isobel A. Scarisbrick and Michael Blaber] 2778

613. Kallikrein-related Peptidase 7 [Christopher J. Farady, Lorenz M. Mayr and Fabrice A. Kolb] 2788

614. Kallikrein-Related Peptidase 8 [Azza Eissa and Eleftherios P. Diamandis] 2792

615. Human Tissue Kallikrein 10 [Liu-Ying Luo and Eleftherios P. Diamandis] 2798

616. Human Kallikrein 11 or Hippostasin [Nozomi Yamaguchi] 2802

617. Kallikrein-related Peptidase 13 [Daniela Cretu and Eleftherios P. Diamandis 2805

618. Kallikrein-related Peptidase 14 [Azza Eissa and Eleftherios P. Diamandis] 2809

619. Kallikrein-related Peptidase 15 (Prostinogen)[Jyotsna Batra and Judith Clements] 2814

620. The Rat and Mouse Kallikrein Gene Clusters [Ake Lundwall] 2818

621. Mouse Proteinase A [Julie Chao] 2824

622. Mouse Kallikreins mK13 and mK26 [Kazuo Hosoi and Chenjuan Yao] 2826

623. Mouse r-Renin, Kallikrein 16 [Julie Chao] 2829

624. Mouse Kallikrein 9, Epidermal Growth Factor-binding Protein [Julie Chao] 2830

625. Mouse r-nerve Growth Factor [Julie Chao] 2831

626. Mouse Proteinase F [Julie Chao] 2833

627. Rat Tissue Kallikrein [Julie Chao] 2835

628. Rat Kallikrein 2, Tonin [Julie Chao] 2837

629. Rat Kallikrein 10, Salivary Gland Proteinase K [Julie Chao] 2840

630. Complement Factor D [F. Forneris and P. Gros] 2841

631. Complement Component C1r [Christine Gaboriaud, Nicole Thielens and Gerard Arlaud] 2849

632. Complement Component C1s [Gerard J. Arlaud, Veronique Rossi, Christine Caboriaud and Nicole M. Thielens] 2853

633. Mannan-binding Lectin-associated Serine Proteases [Wilhelm J. Schwaeble, Nicholas J. Lynch, Peter Gal and Peter Zavodszky] 2857

634. Complement Component C2: the Classical and Lectin Pathway C3/C5 Convertases [Michael A. Kerr] 2863

635. Factor B and the Alternative Pathway C3/C5 Convertase [Michael A. Kerr] 2869

636. Complement Factor I [Robert B. Sim] 2875

637. Coagulation Factor XIla [Alvin H. Schmaier] 2881

638. Prekallikrein and Plasma Kallikrein [Alvin H. Schmaier] 2885

639. Coagulation Factor XIa [Peter N. Walsh] 2892

640. Coagulation Factor IXa [Paul E. Monahan, William H. Velander and S. Paul Bajaj] 2898

641. Coagulation Factor Vila [James H. Morrissey] 2905

642. Coagulation Factor Xa [Mark A. Brown, Leisa M. Stenberg and Johan Stenflo] 2908

643. Thrombin [Bernard F. Le Bonniec] 2915

644. Protein C [Lei Shen and Bjorn Dahlback] 2932

645. u-Plasminogen Activator [Vincent Ellis] 2938

646. t-Plasminogen Activator [H.R. Lijnen and D.C. Rijken] 2946

647. Earthworm Fibrinolytic Enzymes [Yuan Zhou and Rong-Qiao He] 2953

648. Plasmin [Francis J. Castellino] 2958

649. Matriptase [Chen-Yong Lin, Ya-Wen Chen, Zhenghong Xu and Michael D. Johnson] 2969

650. Matriptase-2 [Andrew J. Ramsay, Agnieszka Kwarciak, John D. Hooper, Carlos Lopez-Otin and Gloria Velasco] 2975

651. Adrenal Secretory Protease [Adam Lesner and Magdalena Wysocka] 2983

652. Hepsin [Qingyu Wu and Jianhao Peng] 2985

653. Polyserases [Angela Moncada-Pazos, Santiago Cal and Carlos Lopez-Otin] 2990

654. DESC1 and HAT Peptidases [Toni M. Antalis, Erik W. Martin and Kathryn M. Hodge] 2995

655. Testisin [Toni M. Antalis and Kathryn M. Hodge] 3000

656. Epitheliasin [Narayanam V, Rao and John R. Hoidal] 3003

657. Corin [Ningzheng Dong and Qingyu Wu] 3007

658. Prostasin [Julie Chao, Li-Mei Chen and Karl X. Chai] 3011

659. Guanidinobenzoatase [Frank Steven] 3014

660. Hepatocyte Growth Factor Activator [Hiroaki Kataoka] 3016

661. Hyaluronan-Binding Protease [Michael Etscheid and Johannes Dodt] 3021

662. Venombin A [Francis S. Markland Jr and Stephen Swenson] 3025

663. Venombin AB [Hubert Pirkle and Francis S. Markland Jr] 3034

664. Russell's Viper Venom Factor V Activator [Stephen Swenson and Francis S. Markland Jr] 3036

665. Scutelarin (Oscutarin)[J. Rosing] 3039

666. Platelet-Aggregating Endopeptidase of Bothrops jararaca Venom [Solange M.T. Serrano] 3041

667. Bothrops Protease A [Solange M.T. Serrano] 3043

668. Protein C Activators from Snake Venom [Priscila Oliveira de Giuseppe, Tatiana de Arruda Campos Brasil de Souza, Mario Tyago Murakami, Christian Betzel and Raghuvir Krishnaswamy Arni] 3045

669. Brachyurins [Michael J. Page and Charles S. Craik] 3049

670. Hypodermins A and B [Nathalie Moire] 3053

671. Serine Endopeptidase Allergens from Dermatophagoides Species [Toshiro Takai] 3055

672. Limulus Coagulation Factor C [Shun-ichiro Kawabata, Tatsushi Muta and Sadaaki Iwanaga] 3060

673. Limulus Coagulation Factor B [Shun-ichiro Kawabata, Tatsushi Muta and Sadaaki Iwanaga] 3063

674. Limulus Clotting Enzyme [Shun-ichiro Kawabata, Tatsushi Muta and Sadaaki Iwanaga] 3064

675. Limulus Coagulation Factor G [Shun-ichiro Kawabata, Tatsushi Muta and Sadaaki Iwanaga] 3066

676. Prophenoloxidase-activating Enzyme [Kenneth Soderhall, Anchalee Tassanakajon and Piti Amparyup] 3068

677. Snake Protease of Drosophila [Robert DeLotto] 3074

678. Easter Protease of Drosophila [Robert DeLotto] 3076

679. Gastrulation Defective Protease of Drosophila [Robert DeLotto] 3079

680. Nudel Protease of Drosophila [Ellen K. LeMosy] 3081

681. Alkaline Endopeptidase (Nesterenkonia)[Na Yang and Xiao-Dong Su] 3084

682. IgA1-Specific Serine Endopeptidase [Knud Poulsen and Mogens Kilian] 3088

683. Serine Protease Autotransporters of Enterobacteriaceae [Fernando Navarro-Garda] 3092

684. Hap Gene Product of Haemophilus Influenzae [Joseph W. St. Geme III] 3099

685. Ssy5 Peptidase: A Chymotrypsin-Like Signaling Protease in Yeast [Thorsten Pfirrmann and Per O. Ljungdahl] 3103

686. Togavirin [Martin D. Ryan] 3110

687. Flavivirin [Beate M. Kummerer, Sean M. Amberg and Charles M. Rice] 3112

688. Hepacivirin [Christian Steinkuhler] 3120

689. Potyvirus P1 Proteinase [Adrian Valli] 3130

690. Pestivirus NS2-3/NS3 Serine Peptidase [Norbert Tautz and Heinz-Jurgen Thiel] 3133

691. Arterivirus Serine Endopeptidase [Eric J. Snijder and Alexander E. Gorbalenya] 3137

692. Sobemovirus Peptidase [K. Govind, M.R.N. Murthy and H.S. Savithri] 3141

693. Subtilisins [Thomas P. Graycar, Richard R. Bott, Scott D. Power and David A. Estell] 3148

694. Subtilase Cytotoxin (SubAB)[Kinnosuke Yahiro, Joel Moss and Masatoshi Noda] 3155

695. Cold Adapted Subtilases [Magnus Mar Kristjansson] 3161

696. Thermitase [Ch. Betzel] 3167

697. Bacillopeptidase F [James H. Hageman] 3170

698. Thermus Strain Rt41A Protease [H.S. Toogood and R.M. Daniel] 3171

699. Aqualysin I [Masayoshi Sakaguchi] 3174

700. Bacillus Strain AK.1 Protease [H.S. Toogood and R.M. Daniel] 3177

701. IspA Peptidase [Sung Goo Park and Byoung Chui Park] 3179

702. Endopeptidase Q [Hong Feng, Hai-Yan Wang and Yi-Zheng Zhang] 3182

703. Lactocepin: the Cell Envelope-associated Endopeptidase of lactococci [Jeff R. Broadbent and James L. Steele] 3188

704. Cell Envelope Proteinase A (Streptococcus)[Richard A. Lawrenson and Shiranee Sriskandan] 3195

705. C5a Peptidase [Todd F. Kagawa and Jakki C. Cooney] 3202

706. ASP Peptidase [Eizo Takahashi and Keinosuke Okamoto] 3209

707. Dichelobacter (Sheep Footrot) Basic Serine Proteinase [Corrine Porter and Wilson Wong] 3213

708. Dentilisin [Veli-Jukka Uitto] 3217

709. Lantibiotic Leader Peptidases [Gabriele Bierbaum, Ralph W. Jack and Hans-Georg Sahl] 3220

710. Tripeptidyl-Peptidase S [Michael J. Butler] 3222

711. Archaean Serine Proteases [Elena Sacco, Maria Elena Regonesi and Marco Vanoni] 3224

712. Cerevisin [Rajesh R. Naik and Elizabeth W. Jones] 3233

713. Oryzin [P.E. Kolattukudy and Tatiana D. Sirakova] 3237

714. Proteinase K [W. Saenger] 3240

715. Cuticle-Degrading Endopeptidase [Raymond J. St. Leger] 3242

716. Thermomycolin [G.M, Gaucher and Kenneth J. Stevenson] 3245

717. Plant Subtilisins [Andreas Schaller] 3247

718. Cucumisin [Kazunari Arima, Tetsuya Uchikoba, Hiroo Yonezawa and Makoto Kaneda] 3254

719. Leucyl Endopeptidase [Patrizia Aducci and Paolo Ascenzi] 3258

720. Plasmodium Subtilisins [Natalie C. Silmon de Monerri, Andrea Ruecker and Michael J. Blackman] 3260

721. Site-1 Protease [Nabil G. Seidah] 3265

722. Kexin [Robert S. Fuller] 3270

723. Limulus Kexin [Shun-ichiro Kawabata and Sadaaki Iwanaga] 3277

724. Proprotein Convertases of Caenorhabditis Elegans [A.M. Rose and C. Thacker] 3278

725. Furin [Jeroen Declercq and John W.M. Creemers] 3281

726. Proprotein Convertase 1/3 [Nabil G. Seidah] 3286

727. Proprotein Convertase 2 [Nabil G. Seidah] 3290

728. Proprotein Convertase 4 [Nabil G. Seidah] 3295

729. Proprotein Convertase PACE4 [Tetsuya Akamatsu] 3299

730. Proprotein Convertase 5 [Nabil G. Seidah] 3305

731. Proprotein Convertase 7 [Nabil G. Seidah] 3310

732. Proprotein Convertase PCSK9 [Nabil C. Seidah] 3315

733. Bacterial Members of Subfamily S8B [Gerhard Heussipp] 3322

734. Tripeptidyl-peptidase II [Birgitta Tomkinson and Sandra Eklund] 3325

735. Sedolisin [Kohei Oda] 3331

736. Sedolisin-B [Kohei Oda] 3337

737. Kumamolisin [Kohei Oda] 3339

738. Kumamolisin-As [Toru Nakayama] 3344

739. Physarolisin [Wataru Nishii, Kimiko Murakami-Murofushi and Kenji Takahashi] 3347

740. Tripeptidyl Peptidase I [Istvan Sohar, David E. Sleat and Peter Lobel] 3350

741. Scytalidolisin [Kohei Oda] 3356

742. Prolyl Oligopeptidase [Kiyoshi Ito, Yoshitaka Nakajima and Tadashi Yoshimoto] 3360

743. Oligopeptidase B [Rory E. Morty and Barbara A. Burleigh] 3364

744. Prolyl Tripeptidylpeptidase [Yoshitaka Nakajima, Kiyoshi Ito and Tadashi Yoshimoto] 3371

745. Dipeptidyl-peptidase IV [Yoshio Misumi and Yukio Ikehara] 3374

746. Dipeptidyl Peptidase 8 [Catherine Anne Abbott and Mark D. Gorrell] 3379

747. Dipeptidyl-peptidase 9 [Ingrid De Meester] 3384

748. Dipeptidyl-peptidases A and B [Yoshio Misumi and Yukio Ikehara] 3390

749. Dipeptidyl-peptidases IV and V of Aspergillus [Michel Monod and Anne Beauvais] 3392

750. Fibroblast Activation Protein α [Mark D. Gorrell and John E. Park] 3395

751. Acylaminoacyl-Peptidase [Carmela R. Abraham and Michael W. Nagle] 3401

752. Acylaminoacyl Peptidase (Aeropyrum)[Laszlo Polgar] 3404

753. Carboxypeptidase C including Carboxypeptidase Y [Uffe H. Mortensen, Kjeld Olesen and Klaus Breddam] 3408

754. Lysosomal Carboxypeptidase A [Alexey V. Pshezhetsky] 3413

755. Serine Carboxypeptidase D [S. James Remington] 3418

756. Peptidyl-Glycinamidase [William H. Simmons] 3422

757. X-Pro Dipeptidyl-Peptidase [Jean-Franqois Chich] 3423

758. Lysosomal Pro-Xaa Carboxypeptidase [Fulong Tan, Randal A. Skidgel and Ervin G. Erdos] 3425

759. Dipeptidyl-Peptidase II [Ingrid De Meester] 3432

760. Prolyl Aminopeptidase [Kiyoshi Ito, Yoshitaka Nakajima and Tadashi Yoshimoto] 3438

761. Tripeptidyl-Peptidases A, B and C [Michael J. Butler] 3443

762. Acid Prolyl Endopeptidase [Kenji Takahashi] 3446

763. Penicillin-Binding Protein 5, a Serine-type D-Ala-D-Ala Carboxypeptidase A [Jean-Marc Wilkin] 3448

764. Murein DD-Endopeptidase/PBP-7 [Markus F. Templin and Joachim-Volker Holtje] 3452

765. Streptomyces K15 D-Ala-D-Ala Transpeptidase [Paulette Charlier, Jean-Marie Ghuysen and Jean-Marie Frere] 3454

766. Streptomyces R61 D-Ala-D-Ala Carboxypeptidase [Rex F. Pratt and Jean-Marie Frere] 3458

767. D-Stereospecific Aminopeptidase [Yasuhisa Asano] 3463

768. Alkaline D-Peptidase [Yasuhisa Asano] 3467

769. Penicillin-Binding Protein 4 [David I. Roper and Jeremy J.R.H. Tame] 3470

770. Penicillin-Binding Protein 5 of Escherichia coli [Malika Kumarasiri, Jed F. Fisher and Shahriar Mobashery] 3474

771. Actinomadura R39 D-Ala-D-Ala Carboxypeptidase [Eric Sauvage and Jean-Marie Frere] 3480

772. Repressor LexA [John W. Little] 348

773. UmuD and UmuD' Proteins [Mark Paetzel and Roger Wood gate] 3487

774. Signal Peptidase I [Ross E. Dalbey] 3493

775. Signal Peptidases of Bacillus subtilis [Jan Maarten van Dijl] 3497

776. SpsB Signal Peptidase [David A. Harris and Floyd E. Romesberg] 3501

777. Organellar Signal Peptidases [Jeremy C.L. Packer and Christopher J. Howe] 3508

778. Signal Peptidase (Eukaryote)[Stephen J. Walker and Mark O. Lively] 3512

779. Birnavirus VP4 Processing Endopeptidase [Bernard Defmas, Egbert Mundt and Alexander E. Gorbalenya] 3517

780. Tellina virus 1 VP4 peptidase [Ivy Yeuk Wah Chung and Mark Paetzel] 3523

781. Lon-A Peptidase, Endopeptidase La [Chin Ha Chung and Alfred L. Goldberg] 3527

782. Mitochondrial ATP-Dependent Lon Protease [Jae Lee, Venkatesh Sundararajan, Irene Lee and Carolyn K. Suzuki] 3533

783. Cytomegalovirus Assemblin and Precursor [Wade Gibson] 3540

784. Kaposi's Sarcoma Virus Assemblin (Herpesvirus 8-type Assemblin)[Tina Shahian and Charles S. Craik] 3545

785. Human Herpesvirus Type 6 Assemblin [Ray Jupp, John Mills, Natalie J. Tigue and John Kay] 3550

786. Epstein-Barr Virus Assemblin [Ray Jupp, Alison Ritchie, Michael Robinson, Anne Broad hurst and John Mills] 3552

787. Varicella-Zoster Virus Assemblin [David McMillan, Ray Jupp, John Mills and John Kay] 3555

788. gpO Peptidase (Enterobacteria phage P2) [Terje Dokland] 3557

789. Bacteriophage T4 Prohead Endopeptidase [Neil D. Rawlings] 3560

790. Drosophila Rhomboid-1 [Kvido Strisovsky] 3563

791. Pcp1 Protein (Yeast)[Michael Zick and Andreas S. Reichert] 3567

792. Mammalian Rhomboid Proteases [Sinisa Urban] 3573

793. Bacterial and Protozoan Rhomboid Proteases [Sinisa Urban] 3581

794. Endopeptidase Clp [Michael R. Maurizi] 3593

795. Clp Endopeptidase Homologs in Plants and Animals [Zach Adam, Adrian K. Clarke and Michael R. Maurizi] 3600

796. Tsp Protease [Kenneth C. Keiler] 3605

797. C-Terminal Processing Peptidase of Chloroplasts [Aidong Zhang and Weiguo Li] 3607

798. Signal Peptide Peptidase A (Prokaryotes)[Ross E. Dalbey and Peng Wang] 3611

799. Tricorn Protease [Tomohiro Tamura and Wolfgang Baumeister] 3614

800. Chlamydial Protease/Proteasome-Like Activity Factor [Jijie Chai and Guangming Zhong] 3616

801. Dipeptidase E [Charles C. Miller] 3623

802. Cyanophycinase [Matthew S. Kimber] 3625

803. Murein Tetrapeptide LD-Carboxypeptidases [Markus F. Templin and Joachim-Volker Holtje] 3629

804. Self-Cleaving Mucins [Torleif Hard] 3632

805. Lactoferrin [Andrew C. Plaut and Joseph St. Geme] 3635

806. Dipeptidyl-Peptidase 7 of Porphyromonas gingivalis [Jan Potempa, Agnieszka Banbula and James Travis] 3641

807. Sporulation Factor SpolVB [Ngo Thi Hoa and Simon Cutting] 3643

808. Introduction: Clan PB Containing N-terminal Nucleophile Peptidases [Neil D. Rawlings and Alan J. Barrett] 3648

809. Self-Processing Cysteine-Dependent N-terminal Nucleophile Hydrolases [Bauke W. Dijkstra and Janet L. Smith] 3653

810. Dipeptidase DA [Edward G. Dudley and James L. Steele] 3657

811. Cephalosporin Acylase Precursor, ClutaryI-7-aminocephalosporanic Acid Acylase Precursor [Ki Joon Cho and Kyung Hyun Kim] 3659

812. DmpA L-Aminopeptidase D-Ala Esterase/Amidase of Ochrobactrum Anthropi [Jean-Marie Frere and Jozef Van Beeumen] 3663

813. Archaean Proteasome [Andrei Lu pas, Mary Kania and Wolfgang Baumeister] 3666

814. Bacterial Proteasome [Gang Un, Huilin Li and Carl F. Nathan] 3671

815. HslVU Protease [Eunyong Park, Soon Ji Voo, Ihn Sik Seong and Alfred L. Goldberg and Chin Ha Chung] 3677

816. Eukaryotic 20S Proteasome [Melissa Ann Grawert and Michael Groll] 3684

817. The 26S Proteasome [Stefan Bohn and Friedrich Forster] 3691

818. Glycosylasparaginase Precursor and other Self-Processing N-terminal Nucleophile Amidohydrolases [Nathan N. Aronson Jr] 3701

819. Isoaspartyl Aminopeptidase (Threonine Type)[Karolina Michalska and Mariusz Jaskolski] 3705

820. q-Glutamyl Transpeptidase and its Precursor [Jun Hiratake, Hideyuki Suzuki, Keiichi Fukuyama, Kei Wada and Hidehiko Kumagai] 3712

821. CapD PoIy-r-glutamate Hydrolase/Transpeptidase [Thomas Candela] 3719

822. Taspasel [Luis Cunha, Liang Tong and James J.-D. Hsieh] 3723

823. Polycystin-1 [Feng Qian] 3728

824. Introduction: Unsequenced Serine Peptidases [Alan J. Barrett] 3737

825. Endopeptidase So [Chin Ha Chung and Alfred L. Goldberg] 3737

826. VIPase: Antibody Light Chain Hydrolyzing Vasoactive Intestinal Peptide [Yasuhiro Nishiyama and Sudhir Paul] 3739

UNCLASSIFIED PEPTIDASES

827. Introduction: Peptidases of Unknown Catalytic Type [Neil D. Rawlings and Alan Barrett] 3747

828. Cancer Procoagulant [Stuart G. Gordon and Wojciech P. Mielicki] 3749

829. Glu-GIu Dipeptidase [J. Ken McDonald] 3753

830. Non-Stereospecific Dipeptidase [J. Ken McDonald] 3754

831. LD-Dipeptidase [Micheline Guinand] 3756

832. N-Formylmethionyl Peptidase [Murray Broom] 3757

833. Destabilase [Ludmila L. Zavalova and Isolda P. Baskova] 3758

834. Murein Endopeptidase P5 [Javier Caldentey] 3760

835. Lit Protease [Nikki A. Copeland and Colin Kleanthous] 3761

Index 3765

中国农科院农业信息研究所